Search on:
DNA TOPOISOMERASES, TYPE II
Descriptors Found:
1
Displaying:
1 .. 1
1 / 1
DeCS
Descriptor
English
:
DNA Topoisomerases, Type II
Descriptor
Spanish
:
Topoisomerasas de ADN Tipo II
Descriptor
Portuguese
:
DNA Topoisomerases Tipo II
Synonyms
English
:
DNA Topoisomerase (ATP-Hydrolysing)
DNA Topoisomerase II
Tree Number:
D08.811.399.403.741
Definition
English
:
DNA TOPOISOMERASES
that catalyze ATP-dependent breakage of both strands of
DNA
, passage of the unbroken strands through the breaks, and rejoining of the broken strands. These
enzymes
bring about
relaxation
of the supercoiled
DNA
and resolution of a knotted circular
DNA
duplex.
Indexing Annotation
English
:
coordinate with
BACTERIAL PROTEINS
or
ARCHAEAL PROTEINS
if pertinent
Entry Combination - descr/qualif
English
:
DNA Topoisomerases, Type II
/
antagonists & inhibitors
use
Topoisomerase II Inhibitors
History Note
English
:
2002; use DNA GYRASE 1980-1993
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
31731
Unique Identifier:
D004250
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS